New Indocyanine Derivatives for the Synthesis of Fluorescently Labeled Oligonucleotides

Edward   N.   Timofeev; Victoria   E.   Kuznetsova; Alexander   S.   Zasedatelev; Alexander   V.   Chudinov

doi:10.2174/157017809787003160

Abstract

New sulfonated Cy3 and Cy5 phosphoramidites and solid supports were synthesized. These building blocks were used in the synthesis of terminally or internally labeled oligodeoxynucleotides. Mild deprotection schemes were applied to the sulfocyanine-labeled oligonucleotides.

Keywords: Oligonucleotides, fluorescent label, phosphoramidites, controlled pore glass, indocyanines, deprotection

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Letters in Organic Chemistry

Title: New Indocyanine Derivatives for the Synthesis of Fluorescently Labeled Oligonucleotides

Volume: 6 Issue: 1

Author(s): Edward N. Timofeev, Victoria E. Kuznetsova, Alexander S. Zasedatelev and Alexander V. Chudinov

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Keywords: Oligonucleotides, fluorescent label, phosphoramidites, controlled pore glass, indocyanines, deprotection

Abstract: New sulfonated Cy3 and Cy5 phosphoramidites and solid supports were synthesized. These building blocks were used in the synthesis of terminally or internally labeled oligodeoxynucleotides. Mild deprotection schemes were applied to the sulfocyanine-labeled oligonucleotides.

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Timofeev N. Edward, Kuznetsova E. Victoria, Zasedatelev S. Alexander and Chudinov V. Alexander, New Indocyanine Derivatives for the Synthesis of Fluorescently Labeled Oligonucleotides, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003160