The Stereoselective Total Synthesis of (1S,1R,5R,7R)-1-hydroxy-exo- Brevicomin by a Chiron Approach

Title: The Stereoselective Total Synthesis of (1S,1R,5R,7R)-1-hydroxy-exo- Brevicomin by a Chiron Approach

Volume: 6 Issue: 1

Author(s): Jhillu S. Yadav, Kodepelly Sanjeeva Rao and Basi V. Subba Reddy

Affiliation:

Keywords: D-glucono-δ-lactone, grignard cross coupling, wacker oxidation, acetalization, exo-brevicomin

Abstract: (1S,1R,5R,7R)-1-Hydroxy-exo-brevicomin has been synthesized in a highly efficient manner using Dglucono- δ-lactone as a chiral precursor. The synthesis involves the Grignard cross coupling, Wacker oxidation and intramolecular acetalization as the key steps.

Cite this article as:

Yadav S. Jhillu, Rao Sanjeeva Kodepelly and Subba Reddy V. Basi, The Stereoselective Total Synthesis of (1S,1R,5R,7R)-1-hydroxy-exo- Brevicomin by a Chiron Approach, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003197