NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors

Yu      Mingyan; Liu      Xinyong; Erik      De Clercq

doi:10.2174/138955709787001677

Abstract

NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.

Keywords: AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK

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Mini-Reviews in Medicinal Chemistry

Title: NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors

Volume: 9 Issue: 1

Author(s): Yu Mingyan, Liu Xinyong and Erik De Clercq

Affiliation:

Keywords: AIDS, HIV-1, NF-κB, transcription, inhibitor, LTR, IκB, IKK

Abstract: NF-kappaB (NF-κB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-κB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-κB in triggering HIV-1 transcription and the status of the inhibitors.

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Mingyan Yu, Xinyong Liu and De Clercq Erik, NF-κB: The Inducible Factors of HIV-1 Transcription and their Inhibitors, Mini-Reviews in Medicinal Chemistry 2009; 9 (1) . https://dx.doi.org/10.2174/138955709787001677