The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors

Title: The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors

Volume: 8 Issue: 12

Author(s): Katarzyna Kulig and Marta Szwaczkiewicz

Affiliation:

Keywords: γ-Aminobutyric acid, GABA, GABA uptake antagonist, GABA transporter, GAT

Abstract: γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system (CNS). A decrease in GABAergic neurotransmission seems to be involved in neurological pathologies such as epilepsy, anxiety and pain. This review is focus on structure activity relationship studies aiming the search for new GABA uptake inhibitors.

Cite this article as:

Kulig Katarzyna and Szwaczkiewicz Marta, The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors, Mini-Reviews in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/138955708786141070