Synthesis of 5-(Carbohydrate-ethynyl)-2-deoxyuridine Derivatives

Ruchun      Yang; Haixin      Ding; Yang      Song; Weihong      Xiao; Qiang      Xiao; Jun      Wu

doi:10.2174/157017808785982185

Abstract

Sonogashira reaction has been successfully applied to the synthesis of a series of 5-(carbohydrate-ethynyl)-2- deoxyuridines for the first time. The synthetic route is general, high-yielding and compatible with the readily removable protecting group.

Keywords: Sonogashira reaction, 5-iodo-2'-deoxyuridine, 2-propynyl β-D-glycosides, nucleosides derivatives, Palladium catalysis, cross coupling reaction

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Letters in Organic Chemistry

Title: Synthesis of 5-(Carbohydrate-ethynyl)-2-deoxyuridine Derivatives

Volume: 5 Issue: 7

Author(s): Ruchun Yang, Haixin Ding, Yang Song, Weihong Xiao, Qiang Xiao and Jun Wu

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Keywords: Sonogashira reaction, 5-iodo-2'-deoxyuridine, 2-propynyl β-D-glycosides, nucleosides derivatives, Palladium catalysis, cross coupling reaction

Abstract: Sonogashira reaction has been successfully applied to the synthesis of a series of 5-(carbohydrate-ethynyl)-2- deoxyuridines for the first time. The synthetic route is general, high-yielding and compatible with the readily removable protecting group.

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Yang Ruchun, Ding Haixin, Song Yang, Xiao Weihong, Xiao Qiang and Wu Jun, Synthesis of 5-(Carbohydrate-ethynyl)-2-deoxyuridine Derivatives, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982185