Synthesis, DNA-Binding Ability and Biological Activity of C8 Linked G1 Dendrimer-Pyrrolobenzodiazepine Conjugates as Anticancer Agents

Title: Synthesis, DNA-Binding Ability and Biological Activity of C8 Linked G1 Dendrimer-Pyrrolobenzodiazepine Conjugates as Anticancer Agents

Volume: 5 Issue: 7

Author(s): Ahmed Kamal, G. Balakishan, Rajender, K. Sreekanth, D. Rajasekhar Reddy, M. Kashi Reddy, Subrata Sen, Nisha Kurian, Aarti S. Juvekar and Surekha M. Zingde

Affiliation:

Keywords: G1 Poly (aryl ether) dendrimer, Pyrrolobenzodiazepine, Piperazine, Lipophilicity, DNA-binding affinity and cytotoxicity

Abstract: Some pyrrolo[2,1-c][1,4]benzodiazepine-G1 poly (aryl ether) dendrimer hybrids have been synthesized and evaluated for their DNA binding ability as well as anticancer activity. The linkage of dendrimer component significantly increased DNA binding ability and anticancer activity apart from the enhancement of their solubility, and taking part as a drug carrier.

Cite this article as:

Kamal Ahmed, Balakishan G., Rajender , Sreekanth K., Reddy Rajasekhar D., Reddy Kashi M., Sen Subrata, Kurian Nisha, Juvekar S. Aarti and Zingde M. Surekha, Synthesis, DNA-Binding Ability and Biological Activity of C8 Linked G1 Dendrimer-Pyrrolobenzodiazepine Conjugates as Anticancer Agents, Letters in Drug Design & Discovery 2008; 5 (7) . https://dx.doi.org/10.2174/157018008785909859

DOI https://dx.doi.org/10.2174/157018008785909859	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X