Lanthanide(III) Chelates for Selective Solution Phase Labeling of Biomolecules

Janne      Ketola; Lassi      Jaakkola; Jari      Hovinen

doi:10.2174/157017808785740462

Abstract

Synthesis of photoluminescent lanthanide(III) chelates that allow selective solution phase labeling of bioactive molecules using phosphate elimination, native chemical ligation, and ‘click-chemisty’ is described.

Keywords: Native chemical ligation, phosphate elimination, ‘click chemistry’, lanthanide(III) chelates, labeling

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Letters in Organic Chemistry

Title: Lanthanide(III) Chelates for Selective Solution Phase Labeling of Biomolecules

Volume: 5 Issue: 6

Author(s): Janne Ketola, Lassi Jaakkola and Jari Hovinen

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Keywords: Native chemical ligation, phosphate elimination, ‘click chemistry’, lanthanide(III) chelates, labeling

Abstract: Synthesis of photoluminescent lanthanide(III) chelates that allow selective solution phase labeling of bioactive molecules using phosphate elimination, native chemical ligation, and ‘click-chemisty’ is described.

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Ketola Janne, Jaakkola Lassi and Hovinen Jari, Lanthanide(III) Chelates for Selective Solution Phase Labeling of Biomolecules, Letters in Organic Chemistry 2008; 5 (6) . https://dx.doi.org/10.2174/157017808785740462