Recent Progress of Src Family Kinase Inhibitors as Anticancer Agents

Title: Recent Progress of Src Family Kinase Inhibitors as Anticancer Agents

Volume: 8 Issue: 10

Author(s): Xin Cao, Qi-Dong You, Zhi-Yu Li, Xiao-Jian Wang, Xiao-Yun Lu, Xiao-Rong Liu, Dan Xu and Bao Liu

Affiliation:

Keywords: Protein tyrosine kinases, Src family kinases, kinase domain, inhibitor, anticancer, drug design, SH2, SH3

Abstract: Src family of protein tyrosine kinases (SFKs) play key roles in regulating signal transduction in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. Many SFKs inhibitors were designed and synthesized as anticancer agents in the past several years and great progress has been made. Herein, some predominant examples of SFKs inhibitors recently developed are reviewed and special attentions are paid to the most important ATP binding site inhibitors.

Cite this article as:

Cao Xin, You Qi-Dong, Li Zhi-Yu, Wang Xiao-Jian, Lu Xiao-Yun, Liu Xiao-Rong, Xu Dan and Liu Bao, Recent Progress of Src Family Kinase Inhibitors as Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2008; 8 (10) . https://dx.doi.org/10.2174/138955708785740634