Albumin Competitively Inhibits Glycation of Less Abundant Proteins

Title: Albumin Competitively Inhibits Glycation of Less Abundant Proteins

Volume: 15 Issue: 7

Author(s): Hemangi S. Bhonsle, Sameer Kumar Singh, Ghanshyam Srivastava, Ramanamurthy Boppana and Mahesh J. Kulkarni

Affiliation:

Keywords: insulin, glucose, diabetes, vascular complication, MALDI-TOF-MS

Abstract: Glycation, a non-enzymatic reaction between glucose and protein is the primary cause of diabetic complications. Albumin, the most abundant plasma protein undergoes glycation both in vivo and in vitro. The influence of albumin on glycation of less abundant proteins has not been addressed. For the first time, we show that albumin competitively inhibits the glycation of less abundant proteins. This study suggests that at least in the initial stages of diabetes, albumin may protect other proteins from glycation.

Cite this article as:

Bhonsle S. Hemangi, Singh Kumar Sameer, Srivastava Ghanshyam, Boppana Ramanamurthy and Kulkarni J. Mahesh, Albumin Competitively Inhibits Glycation of Less Abundant Proteins, Protein & Peptide Letters 2008; 15 (7) . https://dx.doi.org/10.2174/092986608785133690