Small Molecules Targeting p53 to Improve Antitumor Therapy

Title: Small Molecules Targeting p53 to Improve Antitumor Therapy

Volume: 8 Issue: 9

Author(s): G. L. Beretta, L. Gatti, V. Benedetti, P. Perego and F. Zunino

Affiliation:

Keywords: p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination

Abstract: Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Cite this article as:

Beretta L. G., Gatti L., Benedetti V., Perego P. and Zunino F., Small Molecules Targeting p53 to Improve Antitumor Therapy, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132774