Urea and Acid Induced Unfolding of Fatted and Defatted Human Serum Albumin

Parveen      Salahuddin

doi:10.2174/092986608785203764

Abstract

Urea induced equilibrium unfolding of fatted and defatted human serum albumin (HSA) showed that fatty acid stabilizes native and intermediate states. Similarly acid induced unfolding of fatted and defatted HSA also showed that fatty acid stabilizes NF and FE transitions. These results also showed that five electrostatic interactions along with one buried carboxyl group of acidic amino acid are involved in acid induced unfolding of HSA.

Keywords: Acid induced unfolding, conformational stability, hydrodynamic volume, intrinsic viscosity, urea induced unfolding

« Previous Next »

Rights & Permissions Print Cite

Protein & Peptide Letters

Title: Urea and Acid Induced Unfolding of Fatted and Defatted Human Serum Albumin

Volume: 15 Issue: 8

Author(s): Parveen Salahuddin

Affiliation:

Keywords: Acid induced unfolding, conformational stability, hydrodynamic volume, intrinsic viscosity, urea induced unfolding

Abstract: Urea induced equilibrium unfolding of fatted and defatted human serum albumin (HSA) showed that fatty acid stabilizes native and intermediate states. Similarly acid induced unfolding of fatted and defatted HSA also showed that fatty acid stabilizes NF and FE transitions. These results also showed that five electrostatic interactions along with one buried carboxyl group of acidic amino acid are involved in acid induced unfolding of HSA.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Salahuddin Parveen, Urea and Acid Induced Unfolding of Fatted and Defatted Human Serum Albumin, Protein & Peptide Letters 2008; 15 (8) . https://dx.doi.org/10.2174/092986608785203764