Aptabodies – New Type of Artificial Receptors for Detection Proteins

T.      Hianik; A.      Porfireva; I.      Grman; G.      Evtugyn

doi:10.2174/092986608785203656

Abstract

We report on a new type of artificial receptor formed by hybridization of two DNA aptamers for human thrombin (aptabody). This aptasensor based on multiwalled carbon nanotubes allowed us to detect thrombin with detection limit of 0.3 nM, which was 3 times better in comparison with conventional aptamer.

Keywords: DNA aptamers, Hybridization, Human thrombin, Multiwalled carbon nanotubes, Biosensor, Electrochemical quartz crystal microbalance

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Protein & Peptide Letters

Title: Aptabodies – New Type of Artificial Receptors for Detection Proteins

Volume: 15 Issue: 8

Author(s): T. Hianik, A. Porfireva, I. Grman and G. Evtugyn

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Keywords: DNA aptamers, Hybridization, Human thrombin, Multiwalled carbon nanotubes, Biosensor, Electrochemical quartz crystal microbalance

Abstract: We report on a new type of artificial receptor formed by hybridization of two DNA aptamers for human thrombin (aptabody). This aptasensor based on multiwalled carbon nanotubes allowed us to detect thrombin with detection limit of 0.3 nM, which was 3 times better in comparison with conventional aptamer.

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Hianik T., Porfireva A., Grman I. and Evtugyn G., Aptabodies – New Type of Artificial Receptors for Detection Proteins, Protein & Peptide Letters 2008; 15 (8) . https://dx.doi.org/10.2174/092986608785203656