Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase

Nicholas      Beckloff; Gill      Diamond

doi:10.2174/092986608784567618

Abstract

Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.

Keywords: Antimicrobial peptide, innate immunity, host defense, signal sequence

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Protein & Peptide Letters

Title: Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase

Volume: 15 Issue: 5

Author(s): Nicholas Beckloff and Gill Diamond

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Keywords: Antimicrobial peptide, innate immunity, host defense, signal sequence

Abstract: Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.

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Beckloff Nicholas and Diamond Gill, Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase, Protein & Peptide Letters 2008; 15 (5) . https://dx.doi.org/10.2174/092986608784567618