Computational Analyses of TBC Protein Family in Eukaryotes

Xinjiao      Gao; Changjiang      Jin; Yu      Xue; Xuebiao      Yao

doi:10.2174/092986608784567483

Abstract

Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.

Keywords: TBC domain, phylogenetic tree, USP6, polarized exocytosis, cell cycle, cytokinesis

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Protein & Peptide Letters

Title: Computational Analyses of TBC Protein Family in Eukaryotes

Volume: 15 Issue: 5

Author(s): Xinjiao Gao, Changjiang Jin, Yu Xue and Xuebiao Yao

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Keywords: TBC domain, phylogenetic tree, USP6, polarized exocytosis, cell cycle, cytokinesis

Abstract: Tre-2/Bub2/Cdc16 domain-containing proteins (TBC proteins) participate in wide range cellular processes. With computational approaches, 137 non-redundant TBC proteins from five model organisms were identified and classified into 13 subfamilies base on molecular evolutionary tree. This phylogenetic analysis provides useful functional annotation of newly-identified TBC proteins and guides for further experimentation.

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Gao Xinjiao, Jin Changjiang, Xue Yu and Yao Xuebiao, Computational Analyses of TBC Protein Family in Eukaryotes, Protein & Peptide Letters 2008; 15 (5) . https://dx.doi.org/10.2174/092986608784567483