Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review

Title: Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review

Volume: 8 Issue: 9

Author(s): T. A. Blizzard

Affiliation:

Keywords: hormone replacement therapy, Spiroindenes, Dihydrobenzoxathiins, Benzochromenones, Androstenes

Abstract: Selective Estrogen Receptor Modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-?? selective antagonists and ER-?? agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of the Merck SERM medicinal chemistry effort as published in the literature through early 2008.

Cite this article as:

Blizzard A. T., Selective Estrogen Receptor Modulator Medicinal Chemistry At Merck. A Review, Current Topics in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/156802608784535066