Future Target Molecules for Influenza Treatment

Title: Future Target Molecules for Influenza Treatment

Volume: 8 Issue: 5

Author(s): N. Uchide and H. Toyoda

Affiliation:

Keywords: Influenza virus, chemotherapy, antioxidant, apoptosis, cytokines, superoxide, macrophages

Abstract: Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.

Cite this article as:

Uchide N. and Toyoda H., Future Target Molecules for Influenza Treatment, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223530