Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets

Title: Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets

Volume: 8 Issue: 5

Author(s): Chris Braumann, Judith Tangermann, Christoph A. Jacobi, Joachim M. Muller and Wolfgang Dubiel

Affiliation:

Keywords: Angiogenesis, tumor, COP9 signalosome, curcumin, emodin, taurolidine

Abstract: Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.

Cite this article as:

Braumann Chris, Tangermann Judith, Jacobi A. Christoph, Muller M. Joachim and Dubiel Wolfgang, Novel Anti-Angiogenic Compounds for Application in Tumor Therapy – COP9 Signalosome-Associated Kinases as Possible Targets, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223549