Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage

Title: Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage

Volume: 5 Issue: 3

Author(s): Hamid Bolouri

Affiliation:

Keywords: Personalized medicine, Dosage selection, Genetic polymorphism, Gene expression variability, Gene regulatory networks, Systems biology

Abstract: Simulations of the effects of DNA polymorphisms, transcriptional noise, and epigenetic differences within and among populations suggest highly divergent responses to drug dosage, resulting in considerable risk of adverse effects. These findings highlight the need for personalized calibration of drug dosage.

Cite this article as:

Bolouri Hamid, Inherent Gene Expression Variabilities and the Need for Personalized Drug Dosage, Letters in Drug Design & Discovery 2008; 5 (3) . https://dx.doi.org/10.2174/157018008784084036

DOI https://dx.doi.org/10.2174/157018008784084036	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X