Synthesis of Highly Strained Enediynes and Dienediynes

Title: Synthesis of Highly Strained Enediynes and Dienediynes

Volume: 8 Issue: 6

Author(s): Amit Basak, Sandip Kumar Roy, Basab Roy and Ajoy Basak

Affiliation:

Abstract: Enediynes continue to fascinate scientists working in various domains because of their structural complexity and fascinating biological mode of action. They represent a masterpiece of natures ingenuity. Besides the warhead which is the enediyne moiety, these molecules are equipped with a locking device, a delivery system and a chemical trigger for activation. Upon triggering, the molecules become active and undergo a thermal rearrangement that was disclosed in the early 70 by Masamune and Bergman and commonly known as Bergman cyclization. The reaction is believed to precede through a diradical benzenoid species (a p-benzyne). This review describes the various strategies employed for the synthesis of highly strained enediynes and dienediynes, both naturally occurring and the designed ones.

Cite this article as:

Basak Amit, Roy Kumar Sandip, Roy Basab and Basak Ajoy, Synthesis of Highly Strained Enediynes and Dienediynes, Current Topics in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/156802608783955728