Improved Preparation of Nabumetone by Raney Ni Catalytic Hydrogenation

Fan      Yang; Lixin      Wang; Xianguo      Li; Jianfen      Shen; Jiyu      Wang; Xiaoqi      Yu

doi:10.2174/157017808783955826

Abstract

Nabumetone is efficiently and economically prepared from hydrogenation of 3-methoxycarbonyl-4-(6- methoxy-2-naphthyl) but-3-en-2-one catalyzed by Raney Ni (W-2) under 145.0 psi H2 at 45 C and subsequent acid hydrolysis in 88.1% yield and 99% purity (GC). A high vacuum distillation or rectification purification method is used to improve the whole qualification of nabumetone.

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: Improved Preparation of Nabumetone by Raney Ni Catalytic Hydrogenation

Volume: 5 Issue: 3

Author(s): Fan Yang, Lixin Wang, Xianguo Li, Jianfen Shen, Jiyu Wang and Xiaoqi Yu

Affiliation:

Abstract: Nabumetone is efficiently and economically prepared from hydrogenation of 3-methoxycarbonyl-4-(6- methoxy-2-naphthyl) but-3-en-2-one catalyzed by Raney Ni (W-2) under 145.0 psi H2 at 45 C and subsequent acid hydrolysis in 88.1% yield and 99% purity (GC). A high vacuum distillation or rectification purification method is used to improve the whole qualification of nabumetone.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Yang Fan, Wang Lixin, Li Xianguo, Shen Jianfen, Wang Jiyu and Yu Xiaoqi, Improved Preparation of Nabumetone by Raney Ni Catalytic Hydrogenation, Letters in Organic Chemistry 2008; 5 (3) . https://dx.doi.org/10.2174/157017808783955826