Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Title: Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials

Volume: 8 Issue: 4

Author(s): Jennifer L. West and James J. Moon

Affiliation:

Keywords: Tissue engineering, vascularization, angiogenesis, scaffold, biomaterials

Abstract: Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.

Cite this article as:

West L. Jennifer and Moon J. James, Vascularization of Engineered Tissues: Approaches to Promote Angiogenesis in Biomaterials, Current Topics in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/156802608783790983