Enzymes in Protein Ligation: The Coupling of Peptides, Peptide Nucleic Acids and Proteins by Sortase A

S.      Pritz

doi:10.2174/157019308783498188

Abstract

The chemical synthesis of proteins, as well as the modification of expressed proteins, requires highly selective reactions. Ligation methods offer feasible tools for this purpose. This mini-review focuses on enzymatic methods for protein ligation; in particular, on the use of the transpeptidase sortase.

Keywords: Enzymatic ligation, sortase, proteins, peptides, peptide nucleic acids

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Mini-Reviews in Organic Chemistry

Title: Enzymes in Protein Ligation: The Coupling of Peptides, Peptide Nucleic Acids and Proteins by Sortase A

Volume: 5 Issue: 1

Author(s): S. Pritz

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Keywords: Enzymatic ligation, sortase, proteins, peptides, peptide nucleic acids

Abstract: The chemical synthesis of proteins, as well as the modification of expressed proteins, requires highly selective reactions. Ligation methods offer feasible tools for this purpose. This mini-review focuses on enzymatic methods for protein ligation; in particular, on the use of the transpeptidase sortase.

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Pritz S., Enzymes in Protein Ligation: The Coupling of Peptides, Peptide Nucleic Acids and Proteins by Sortase A, Mini-Reviews in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157019308783498188