Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease

Title: Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease

Volume: 8 Issue: 2

Author(s): Nahum Mendez-Sanchez, Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes and Misael Uribe

Affiliation:

Keywords: Iron, iron overload, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease

Abstract: Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/ overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.

Cite this article as:

Mendez-Sanchez Nahum, Baptista-Gonzalez Hector, Chavez-Tapia C. Norberto, Zamora-Valdes Daniel and Uribe Misael, Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver Disease, Mini-Reviews in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/138955708783498087