N-Myristoyltransferase: A Novel Target

Title: N-Myristoyltransferase: A Novel Target

Volume: 8 Issue: 2

Author(s): M. P. Toraskar, K. K. Prasad and V. J. Kadam

Affiliation:

Keywords: N-myristoyltransferase, myristoylation, benzofurans, benzothiazoles, antifungal, Candida albicans, anticancer, antiviral

Abstract: Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid , myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for Anticancer, Antiviral and antifungal agents. Recent Nmyristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.

Cite this article as:

Toraskar P. M., Prasad K. K. and Kadam J. V., N-Myristoyltransferase: A Novel Target, Mini-Reviews in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/138955708783498159