Bacterial β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH): An Attractive Target for the Design of New Broad-Spectrum Antimicrobial Agents

Miguel   Angel Cabrera   Perez; Yunierkis   Perez   Castillo

doi:10.2174/138955708783331559

Abstract

The emergence of drug resistant strains of important human pathogens has made urgent the necessity of finding new targets and novel antimicrobial agents. One of the most promising targets is FabH. In this review we summarize the progress made in the design of FabH inhibitors and the role played by the 3D-structure of the enzyme in the drug design process.

Keywords: FabH, FAS, FabH inhibitors, drug design

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Mini-Reviews in Medicinal Chemistry

Title: Bacterial β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH): An Attractive Target for the Design of New Broad-Spectrum Antimicrobial Agents

Volume: 8 Issue: 1

Author(s): Miguel Angel Cabrera Perez and Yunierkis Perez Castillo

Affiliation:

Keywords: FabH, FAS, FabH inhibitors, drug design

Abstract: The emergence of drug resistant strains of important human pathogens has made urgent the necessity of finding new targets and novel antimicrobial agents. One of the most promising targets is FabH. In this review we summarize the progress made in the design of FabH inhibitors and the role played by the 3D-structure of the enzyme in the drug design process.

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Perez Angel Cabrera Miguel and Castillo Perez Yunierkis, Bacterial β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH): An Attractive Target for the Design of New Broad-Spectrum Antimicrobial Agents, Mini-Reviews in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/138955708783331559