Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans

Title: Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans

Volume: 4 Issue: 1

Author(s): Atul Goel, Manish Dixit, Uzma Saeed, Amit Kumar, Mohammad Imran Siddiqi, Akhilesh K. Tamrakar and Arvind K. Srivastava

Affiliation:

Keywords: Diabetes, PTP1B inhibitor, 4,5-dihydronaphthofuran, dibenzofuran, molecular docking

Abstract: Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.

Cite this article as:

Goel Atul, Dixit Manish, Saeed Uzma, Kumar Amit, Siddiqi Imran Mohammad, Tamrakar K. Akhilesh and Srivastava K. Arvind, Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans, Medicinal Chemistry 2008; 4 (1) . https://dx.doi.org/10.2174/157340608783331515