S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells

Title: S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells

Volume: 15 Issue: 1

Author(s): Fabrizio D'Anselmi, Alessandra Cucina, Giuseppe Cavallaro, Mariano Bizzarri, Rosaria Adele Cavallaro, Andrea Fuso, Antonino Cavallaro and Sigfrido Scarpa

Affiliation:

Keywords: Ubiquitin-proteasome system, 20S proteasome, S-adenosylmethionine, vascular smooth muscle cells, atherosclerosis, Sulfur-containing aminoacids cycle

Abstract: S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor screening assay, and in rat vascular smooth muscle cells, by Western Blot of proteasomal targets. We found that S-adenosylmethionine inhibited UPS activity.

Cite this article as:

D'Anselmi Fabrizio, Cucina Alessandra, Cavallaro Giuseppe, Bizzarri Mariano, Cavallaro Adele Rosaria, Fuso Andrea, Cavallaro Antonino and Scarpa Sigfrido, S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells, Protein & Peptide Letters 2008; 15 (1) . https://dx.doi.org/10.2174/092986608783330396