Tetraspanins-Structural and Signalling Scaffolds that Regulate Platelet Function

Title: Tetraspanins-Structural and Signalling Scaffolds that Regulate Platelet Function

Volume: 7 Issue: 12

Author(s): Matt W. Goschnick and Denise E. Jackson

Affiliation:

Keywords: Tetraspanin, integrin αIIbβ3, outside-in signalling, platelet thrombus formation

Abstract: There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the ‘outside-in’ signalling properties of the major platelet integrin, integrin αIIbβ3 and thrombus stability in vivo.

Cite this article as:

Goschnick W. Matt and Jackson E. Denise, Tetraspanins-Structural and Signalling Scaffolds that Regulate Platelet Function, Mini-Reviews in Medicinal Chemistry 2007; 7 (12) . https://dx.doi.org/10.2174/138955707782795656