Spectroscopic and Functional Characterization of Human β-Synuclein

Title: Spectroscopic and Functional Characterization of Human β-Synuclein

Volume: 14 Issue: 10

Author(s): Juhyung Lee, Heejin Hwang and T. Doohun Kim

Affiliation:

Keywords: β-Synuclein, circular dichroism, fluorescence, conformational change

Abstract: To elucidate potential biological roles of human β-synuclein, we studied its conformational changes under various conditions. The structural and functional properties of β-synuclein were characterized using biochemical and biophysical methods including: a functional assay, mass spectrometry, size exclusion chromatography, circular dichroism (CD), and fluorescence spectroscopy. The results showed β-synuclein has a high proportion of random coil in solution.

Cite this article as:

Lee Juhyung, Hwang Heejin and Kim Doohun T., Spectroscopic and Functional Characterization of Human β-Synuclein, Protein & Peptide Letters 2007; 14 (10) . https://dx.doi.org/10.2174/092986607782541132