Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology

Title: Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology

Volume: 4 Issue: 4

Author(s): Predrag Cudic and Maciej Stawikowski

Affiliation:

Keywords: Peptidomimetics, pseudopeptides, isosteres, Fmoc solid-phase synthesis

Abstract: Peptidomimetic modifications are frequently used as attractive methods to provide more conformationally constrained and thus more stable and bioactive peptides. Among peptidomimetic approaches, particularly attractive are pseudopeptides, or peptide bond surrogates in which peptide bonds have been replaced with other chemical groups. Since these peptidomimetics can be constructed in a modular way from orthogonally protected monomeric building blocks, solid-phase Fmoc methodology, used routinely for peptide synthesis, emerged as a particularly attractive synthetic approach.

Cite this article as:

Cudic Predrag and Stawikowski Maciej, Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology, Mini-Reviews in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157019307782411716