In Vitro Degradation Of beta-Amyloid[25-35] Peptide

Title: In Vitro Degradation Of beta-Amyloid[25-35] Peptide

Volume: 8 Issue: 6

Author(s): Krisztina Jost, Jozsef Varga, Botond Pence and Marta Zarandi

Affiliation:

Keywords: AMYLOID PEPTIDE, Alzheimer disease

Abstract: Some amyloid-derived peptides show their toxic effects only after a long “aging” period performed several days at pH 7.4 and 37 C for cluster formation. Our experiments show that long aging of beta-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta-amyloids.

Cite this article as:

Jost Krisztina, Varga Jozsef, Pence Botond and Zarandi Marta, In Vitro Degradation Of beta-Amyloid[25-35] Peptide, Protein & Peptide Letters 2001; 8 (6) . https://dx.doi.org/10.2174/0929866013409076