Syntheses of Cholecystokin in (Cck) Fragment Analogues (26-33) and Comparative Effect on Decreased Feeding in Rats by Cck Fragment (26-33)

Title: Syntheses of Cholecystokin in (Cck) Fragment Analogues (26-33) and Comparative Effect on Decreased Feeding in Rats by Cck Fragment (26-33)

Volume: 8 Issue: 2

Author(s): T. Abiko and S. Nakatsubo

Affiliation:

Keywords: cholecystokin cck, cck, cholecystokinin cck

Abstract: The peptide analogues of cholecystokinin (CCK) fragment 26-33 in which phenylalanine residue at the 33th position are replaced by phenylglycine [Phg], 1-naphthylalanine [1-Nal], 4-fluorophenylalanine [Phe(4F)], cyclohexylalanine [cHex] and O-methyltyrosine [Tyr(Me)], were synthesized by a solid-phase method and the feeding significance of the aromatic amino acid of this position was comparatively investigated. The in vivo comparative effect on the decreased feeding in rats by peripherally CCK-8 was tested. The observed activities of these peptides were in order [Phe(4F)33]CCK-8) > .[1-Nal33]CCK-8 > CCK-8 > [Tyr(Me)33]CCK-8 > [Phe33]CCK-8. However, the one analogue, [cHex33]CCK-8, had no inhibitory effect on food intake in rats.

Cite this article as:

Abiko T. and Nakatsubo S., Syntheses of Cholecystokin in (Cck) Fragment Analogues (26-33) and Comparative Effect on Decreased Feeding in Rats by Cck Fragment (26-33), Protein & Peptide Letters 2001; 8 (2) . https://dx.doi.org/10.2174/0929866013409652