Therapeutic Applications of Sugar-Mimicking Glycosidase Inhibitors

Naoki      Asano; Atsushi      Kato; Alison   A.   Watson

doi:10.2174/1389557013407052

Abstract

Sugar-mimicking alkaloids inhibit the glycosidases involved in a wide range of important biological processes, principally owing to their structural resemblance to the sugar moiety of the natural substrate. The possibility of modifying and blocking these processes by using such inhibitors for therapeutic applications has attracted a lot of attention.

Keywords: Glycosidase Inhibitors, glycosidases, Castanospermine, Castanospermum australe, glucosidase inhibitors, Casuarina equisetifolia, Actinoplanes, antidiabetic agents, MANNOSIDASE INHIBITORS

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Mini-Reviews in Medicinal Chemistry

Title: Therapeutic Applications of Sugar-Mimicking Glycosidase Inhibitors

Volume: 1 Issue: 2

Author(s): Naoki Asano, Atsushi Kato and Alison A. Watson

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Abstract: Sugar-mimicking alkaloids inhibit the glycosidases involved in a wide range of important biological processes, principally owing to their structural resemblance to the sugar moiety of the natural substrate. The possibility of modifying and blocking these processes by using such inhibitors for therapeutic applications has attracted a lot of attention.

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Asano Naoki, Kato Atsushi and Watson A. Alison, Therapeutic Applications of Sugar-Mimicking Glycosidase Inhibitors, Mini-Reviews in Medicinal Chemistry 2001; 1 (2) . https://dx.doi.org/10.2174/1389557013407052