Effect of Phospholipid Membrane on Conformation of Retro-Sequence Amyloid- beeta-Peptide 35-25 and Normal Amyloid-beeta-Peptide 25-35

Masato      Kodaka

doi:10.2174/0929866013409274

Abstract

Negatively-charged phospholipid membrane does not affect the random coil conformation of a non-neurotoxic amyloid-beeta-peptide having a retro-sequence 35-25 (Abeta 35-25), whereas it changes the conformation of a neurotoxic normal-sequence peptide A beeta 25-35 from a random coil to a beeta-sheet-like structure under the same condition. The formation of the ordered structure seems to be closely related to the expression of neurotoxicity.

Keywords: AMYLOID PEPTIDE 35-25, AMYLOID PEPTIDE 25-35, amyloid peptide

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Protein & Peptide Letters

Title: Effect of Phospholipid Membrane on Conformation of Retro-Sequence Amyloid- beeta-Peptide 35-25 and Normal Amyloid-beeta-Peptide 25-35

Volume: 8 Issue: 5

Author(s): Masato Kodaka

Affiliation:

Keywords: AMYLOID PEPTIDE 35-25, AMYLOID PEPTIDE 25-35, amyloid peptide

Abstract: Negatively-charged phospholipid membrane does not affect the random coil conformation of a non-neurotoxic amyloid-beeta-peptide having a retro-sequence 35-25 (Abeta 35-25), whereas it changes the conformation of a neurotoxic normal-sequence peptide A beeta 25-35 from a random coil to a beeta-sheet-like structure under the same condition. The formation of the ordered structure seems to be closely related to the expression of neurotoxicity.

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Kodaka Masato, Effect of Phospholipid Membrane on Conformation of Retro-Sequence Amyloid- beeta-Peptide 35-25 and Normal Amyloid-beeta-Peptide 25-35, Protein & Peptide Letters 2001; 8 (5) . https://dx.doi.org/10.2174/0929866013409274