N-Oxides as Hypoxia Selective Cytotoxins

Title: N-Oxides as Hypoxia Selective Cytotoxins

Volume: 1 Issue: 3

Author(s): Hugo Cerecetto and Mercedes Gonzalez

Affiliation:

Keywords: N-Oxides, Hypoxia, Cytotoxins, Tumor Hypoxia, Bioreductive Agents, Imidazopyridopyrazine N-Oxide and Imidazoquin-oxaline N-Oxide, Quinoxaline N,N-Dioxide, Aminoalkylaminoanthraquinone N-Oxide, Aminoalkylaminoacridine N-Oxide

Abstract: N-Oxide-containing compounds have been developed as prodrugs that are selectively bioactivated in the hypoxic cells in tumors. This selectivity is based on the net reduction of the N-oxide moiety in the absence of oxygen, in a one or two-electron process, by reductive enzymes. A wide range of N-oxides have been studied and some of them are currently in clinical use. This review covers the principal families of compounds under study and in clinical trials.

Cite this article as:

Cerecetto Hugo and Gonzalez Mercedes, N-Oxides as Hypoxia Selective Cytotoxins, Mini-Reviews in Medicinal Chemistry 2001; 1 (3) . https://dx.doi.org/10.2174/1389557013406891