Synthesis of Alkyl and Aryl Esters of N-Protected β-Homoamino Acids from N-Protected α-Aminodiazoketones

Title: Synthesis of Alkyl and Aryl Esters of N-Protected β-Homoamino Acids from N-Protected α-Aminodiazoketones

Volume: 9 Issue: 6

Author(s): G. R. Vasanthakumar, H. N. Gopi and V. Suresh Babu

Affiliation:

Keywords: ALKYL, ARYL ESTERS, homoamino acids, AMINODIAZOKETONES

Abstract: A simple and concomitant esterification method for the synthesis of methyl, ethyl, t-butyl, benzyl, and 9-fluorenylmethyl esters of Fmoc- / Boc- / Z-β-homoamino acids employing Fmoc- / Boc- / Z-α- aminodiazoketones by Wolff rearrangement is described. The method offers good yield with purity.

Cite this article as:

Vasanthakumar R. G., Gopi N. H. and Babu Suresh V., Synthesis of Alkyl and Aryl Esters of N-Protected β-Homoamino Acids from N-Protected α-Aminodiazoketones, Protein & Peptide Letters 2002; 9 (6) . https://dx.doi.org/10.2174/0929866023408364