Flexible Crosslinked Benzhydry Support for Gel-Phase Peptide Synthesis

I.M.   Krishna   Kumar; Beena      Mathew

doi:10.2174/0929866023408913

Abstract

An amphiphilic support was developed by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was converted to benzhydryl resin, BDDMA-PS-BH, by a two-step polymer analogous reaction. This resin was employed as a support for the synthesis of delta sleep inducing peptide (DSIP), Trp-Ala-Gly-Gly-Asp-Ala-Ser- Gly-Glu, in high yield and purity by Fmoc / t-Bu tactics.

Keywords: gel, phase peptide, delta sleep inducing peptide, solid-phase peptide

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Protein & Peptide Letters

Title: Flexible Crosslinked Benzhydry Support for Gel-Phase Peptide Synthesis

Volume: 9 Issue: 2

Author(s): I.M. Krishna Kumar and Beena Mathew

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Keywords: gel, phase peptide, delta sleep inducing peptide, solid-phase peptide

Abstract: An amphiphilic support was developed by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was converted to benzhydryl resin, BDDMA-PS-BH, by a two-step polymer analogous reaction. This resin was employed as a support for the synthesis of delta sleep inducing peptide (DSIP), Trp-Ala-Gly-Gly-Asp-Ala-Ser- Gly-Glu, in high yield and purity by Fmoc / t-Bu tactics.

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Kumar Krishna I.M. and Mathew Beena, Flexible Crosslinked Benzhydry Support for Gel-Phase Peptide Synthesis, Protein & Peptide Letters 2002; 9 (2) . https://dx.doi.org/10.2174/0929866023408913