Structure-activity Relationship, Conformation and Pharmacology Studies of Morphiceptin Analogues - Selective μ-Opioid Receptor Ligands

Title: Structure-activity Relationship, Conformation and Pharmacology Studies of Morphiceptin Analogues - Selective μ-Opioid Receptor Ligands

Volume: 2 Issue: 6

Author(s): Anna Janecka, Jakub Fichna, Marek Mirowski and Tomasz Janecki

Affiliation:

Keywords: morphiceptin analogues, opioid receptor ligands, diagnosis, enkephalins, opiate-like properties, receptor ligands, physiological activity, opioid activity, cyclic analogues, potential pharmaceutical agents

Abstract: Morphiceptin (Tyr-Pro-Phe-Pro-NH2) is one of the most selective agonists for the μ-opioid receptor. In this review structure-activity relationships of morphiceptin analogues and studies resulting in defining low energy conformations are discussed. Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers.

Cite this article as:

Janecka Anna, Fichna Jakub, Mirowski Marek and Janecki Tomasz, Structure-activity Relationship, Conformation and Pharmacology Studies of Morphiceptin Analogues - Selective μ-Opioid Receptor Ligands, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405567