Liposomes for Intravenous Drug Targeting: Design and Applications

Josbert   M.   Metselaar; Enrico      Mastrobattista; Gert      Storm

doi:10.2174/1389557023405873

Abstract

Drug targeting with liposomes has been studied for over 25 years and has demonstrated its value in clinical practice. This mini review offers an overview of the design and application of liposomes for i.v. drug targeting. Two approaches are outlined: passive and active targeting. The former approach is based on liposomes with prolonged circulation and selective target localization properties, while in the latter approach specific targeting ligands are coupled to the liposome surface in order to achieve enhanced interaction with target cell membranes.

Keywords: liposome, liposome target

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Mini-Reviews in Medicinal Chemistry

Title: Liposomes for Intravenous Drug Targeting: Design and Applications

Volume: 2 Issue: 4

Author(s): Josbert M. Metselaar, Enrico Mastrobattista and Gert Storm

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Keywords: liposome, liposome target

Abstract: Drug targeting with liposomes has been studied for over 25 years and has demonstrated its value in clinical practice. This mini review offers an overview of the design and application of liposomes for i.v. drug targeting. Two approaches are outlined: passive and active targeting. The former approach is based on liposomes with prolonged circulation and selective target localization properties, while in the latter approach specific targeting ligands are coupled to the liposome surface in order to achieve enhanced interaction with target cell membranes.

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Metselaar M. Josbert, Mastrobattista Enrico and Storm Gert, Liposomes for Intravenous Drug Targeting: Design and Applications, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023405873