Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimers Disease

Title: Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimers Disease

Volume: 2 Issue: 1

Author(s): Ana Castro, Santiago Conde, M. Isabel Rodriguez-Franco and Ana Martinez

Affiliation:

Keywords: Non-Cholinergic Pharmacotherapy, Alzheimers Disease, neurofibrillary tangles, ampakines, acetylcholinesterase (AChE), Tau Hyperphosphorylation, calmoduline kinase

Abstract: Research on the molecular basis of Alzheimers disease has elucidated pathogenic pathways from which a range of rational pharmacological interventions has emerged. The most promising strategies involve approaches to retarding, halting or preventing the formation or accumulation of beta amyloid plaques and neurofibrillary tangles. Other therapeutic approaches include those acting via excitatory amino acid receptors, limiting the oxidative stress and inflammatory response associated with dementia, molecules with nerve growth factor like activity. In the present article these and the other recent advances in the neurobiology and pharmacotherapy of AD will be reviewed.

Cite this article as:

Castro Ana, Conde Santiago, Rodriguez-Franco Isabel M. and Martinez Ana, Non-Cholinergic Pharmacotherapy Approaches to the Future Treatment of Alzheimers Disease, Mini-Reviews in Medicinal Chemistry 2002; 2 (1) . https://dx.doi.org/10.2174/1389557023406610