Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors

Title: Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors

Volume: 3 Issue: 4

Author(s): A. Dimoglo, E. Sim, N. Shvets and V. Ahsen

Affiliation:

Keywords: cox-2, nsaids, structure-activity relationships (sar)

Abstract: A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.

Cite this article as:

Dimoglo A., Sim E., Shvets N. and Ahsen V., Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors, Mini-Reviews in Medicinal Chemistry 2003; 3 (4) . https://dx.doi.org/10.2174/1389557033488060