Guanidinium Rich Peptide Transporters and Drug Delivery

Lee   R.   Wright; Jonathan   B.   Rothbard; Paul   A.   Wender

doi:10.2174/1389203033487252

Abstract

The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variation and use of guanidinium based transporters to facilitate the uptake of various types of molecules into cells and tissues. Lead conjugates in this area are currently in clinical trials.

Keywords: Guanidinium, Drug Delivery, Rich Peptide Transporters

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Current Protein & Peptide Science

Title: Guanidinium Rich Peptide Transporters and Drug Delivery

Volume: 4 Issue: 2

Author(s): Lee R. Wright, Jonathan B. Rothbard and Paul A. Wender

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Keywords: Guanidinium, Drug Delivery, Rich Peptide Transporters

Abstract: The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variation and use of guanidinium based transporters to facilitate the uptake of various types of molecules into cells and tissues. Lead conjugates in this area are currently in clinical trials.

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Wright R. Lee, Rothbard B. Jonathan and Wender A. Paul, Guanidinium Rich Peptide Transporters and Drug Delivery, Current Protein & Peptide Science 2003; 4 (2) . https://dx.doi.org/10.2174/1389203033487252