A Simplified Model Of The Binding Interaction Between Stromal Cell-Derived Factor-1 Chemokine And Cxc Chemokine Receptor 4

Title: A Simplified Model Of The Binding Interaction Between Stromal Cell-Derived Factor-1 Chemokine And Cxc Chemokine Receptor 4

Volume: 10 Issue: 2

Author(s): Pasquale Palladino, Carlo Pedone, Raffaele Ragone, Filomena Rossi, Michele Saviano and Ettore Benedetti

Affiliation:

Keywords: Stromal, Factor-1, CXCR4, peptide, chemokine

Abstract: We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4{29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4{29-39}.

Cite this article as:

Palladino Pasquale, Pedone Carlo, Ragone Raffaele, Rossi Filomena, Saviano Michele and Benedetti Ettore, A Simplified Model Of The Binding Interaction Between Stromal Cell-Derived Factor-1 Chemokine And Cxc Chemokine Receptor 4, Protein & Peptide Letters 2003; 10 (2) . https://dx.doi.org/10.2174/0929866033479022