Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization

Title: Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization

Volume: 10 Issue: 4

Author(s): Naoko Sato, Yosuke Ohtake, Hiroyuki Kohno, Shinya Abe and Yasuhito Ohkubo

Affiliation:

Keywords: transglutaminase, polyamine, putrescine, spermidine, spermine

Abstract: Transglutaminase (TGase) has been reported to be involved in the regulation of cell growth. We examined the effects of polyamines on TGase activity. The polymerization of casein was inhibited by putrescine (PUT) and spermidine (SPD). On the other hand, polymerization of N,N-dimethylcasein was increased by spermine (SPM) and SPD. These results suggested polyamines played two distinct roles as inhibitor and promoter for TGase-catalyzed protein polymerization.

Cite this article as:

Sato Naoko, Ohtake Yosuke, Kohno Hiroyuki, Abe Shinya and Ohkubo Yasuhito, Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization, Protein & Peptide Letters 2003; 10 (4) . https://dx.doi.org/10.2174/0929866033478816