Monitoring Bone Loss Using Elisa and Surface Plasmon Resonance (Spr) Technology

Feng-Di   T.   Lung; Huey-Yi      Chen; Hsing-Tzu      Lin

doi:10.2174/0929866033478997

Abstract

Osteoporosis influences the health of the females who are in menopause phase. The techniques to detect the markers of bone turnover is very important for preventing osteoporosis. ELISA was developed for detection of urinary N-telopeptide (NTx) as an osteoporosis marker. Our aim is to develop a sensitive method to detect NTx excretion using surface plasmon resonance (SPR). Samples collected were assayed and results suggest that our SPR-based method is promising for monitoring bone loss.

Keywords: osteoporosis, bone turnover, bone resorption, n-telopeptide, surface plasmon resonance

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Protein & Peptide Letters

Title: Monitoring Bone Loss Using Elisa and Surface Plasmon Resonance (Spr) Technology

Volume: 10 Issue: 3

Author(s): Feng-Di T. Lung, Huey-Yi Chen and Hsing-Tzu Lin

Affiliation:

Keywords: osteoporosis, bone turnover, bone resorption, n-telopeptide, surface plasmon resonance

Abstract: Osteoporosis influences the health of the females who are in menopause phase. The techniques to detect the markers of bone turnover is very important for preventing osteoporosis. ELISA was developed for detection of urinary N-telopeptide (NTx) as an osteoporosis marker. Our aim is to develop a sensitive method to detect NTx excretion using surface plasmon resonance (SPR). Samples collected were assayed and results suggest that our SPR-based method is promising for monitoring bone loss.

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Lung T. Feng-Di, Chen Huey-Yi and Lin Hsing-Tzu, Monitoring Bone Loss Using Elisa and Surface Plasmon Resonance (Spr) Technology, Protein & Peptide Letters 2003; 10 (3) . https://dx.doi.org/10.2174/0929866033478997