Medicinal Chemistry of Adenosine A1 Receptor Ligands

Willem      Soudijn; Ineke   van   Wijngaarden; Ad   P.   Ijzerman

doi:10.2174/1568026033392165

Abstract

In this review the latest developments in ligand design for the adenosine A1 receptor are summarized. Novel series of agonists and antagonists are discussed, leading to the conclusion that ligands truly selective for the human adenosine A1 receptor are still scarce.

Keywords: adenosine receptor, medicinal chemistry, affinity, intrinsic activity

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Current Topics in Medicinal Chemistry

Title: Medicinal Chemistry of Adenosine A1 Receptor Ligands

Volume: 3 Issue: 4

Author(s): Willem Soudijn, Ineke van Wijngaarden and Ad P. Ijzerman

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Keywords: adenosine receptor, medicinal chemistry, affinity, intrinsic activity

Abstract: In this review the latest developments in ligand design for the adenosine A1 receptor are summarized. Novel series of agonists and antagonists are discussed, leading to the conclusion that ligands truly selective for the human adenosine A1 receptor are still scarce.

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Soudijn Willem, Wijngaarden van Ineke and Ijzerman P. Ad, Medicinal Chemistry of Adenosine A1 Receptor Ligands, Current Topics in Medicinal Chemistry 2003; 3 (4) . https://dx.doi.org/10.2174/1568026033392165