The Use of Molecular Descriptors in the Design of Gadolinium (III) Chelates as MRI Contrast Agents

Alessandro      Maiocchi

doi:10.2174/1389557033487647

Abstract

Nuclear Magnetic Resonance Imaging (MRI) is a very useful tool in modern medical diagnostics, especially when gadolinium(III)-based contrast agents are administered to the patient with the aim of increasing the image contrast between normal and diseased tissues. The main purpose of this review is to show that a new generation of these contrast agents could be developed by making greater use of soft modelling techniques such as QSAR / QSPR after a suitable description of their molecular structure.

Keywords: magnetic resonance imaging, mri, gadolinium, qsar, qspr, molecular descriptors

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Mini-Reviews in Medicinal Chemistry

Title: The Use of Molecular Descriptors in the Design of Gadolinium (III) Chelates as MRI Contrast Agents

Volume: 3 Issue: 8

Author(s): Alessandro Maiocchi

Affiliation:

Keywords: magnetic resonance imaging, mri, gadolinium, qsar, qspr, molecular descriptors

Abstract: Nuclear Magnetic Resonance Imaging (MRI) is a very useful tool in modern medical diagnostics, especially when gadolinium(III)-based contrast agents are administered to the patient with the aim of increasing the image contrast between normal and diseased tissues. The main purpose of this review is to show that a new generation of these contrast agents could be developed by making greater use of soft modelling techniques such as QSAR / QSPR after a suitable description of their molecular structure.

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Maiocchi Alessandro, The Use of Molecular Descriptors in the Design of Gadolinium (III) Chelates as MRI Contrast Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (8) . https://dx.doi.org/10.2174/1389557033487647