Antidepressants in Chronic Neuropathic Pain

Consalvo      Mattia; Flaminia      Coluzzi

doi:10.2174/1389557033487836

Abstract

This review presents available clinical studies and new insights into mechanisms of analgesic effect and possible new routes of administration of antidepressant drugs. Older TCAs continue to be superior treatments. We focused on recent findings on newer antidepressants as analgesics. Their use should be supported by further controlled trials.

Keywords: neuropathic pain, antidepressant, new antidepressant drugs, antinociception, mechanism of action, clinical trials

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Mini-Reviews in Medicinal Chemistry

Title: Antidepressants in Chronic Neuropathic Pain

Volume: 3 Issue: 7

Author(s): Consalvo Mattia and Flaminia Coluzzi

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Keywords: neuropathic pain, antidepressant, new antidepressant drugs, antinociception, mechanism of action, clinical trials

Abstract: This review presents available clinical studies and new insights into mechanisms of analgesic effect and possible new routes of administration of antidepressant drugs. Older TCAs continue to be superior treatments. We focused on recent findings on newer antidepressants as analgesics. Their use should be supported by further controlled trials.

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Mattia Consalvo and Coluzzi Flaminia, Antidepressants in Chronic Neuropathic Pain, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487836