Plant-derived Terpenoids and Analogues as Anti-HIV Agents

Kuo-Hsiung      Lee

doi:10.2174/1568026033392435

Abstract

The plant-derived terpenoids and analogues are reviewed with respect to their anti-HIV activity, structure-activity relationships, and mechanism of action. The active compounds include diterpenoid lactones, phenolic diterpenes, atisane and kaurane diterpenes, phorbol diterpenes, triterpene glycosides, friedelane triterpenes, taraxerane triterpenes, ursane triterpenes, lanostane triterpene, lupane triterpenes, seco-ring A triterpenes, degraded triterpenes, and cucurbitacin triterpenes. Positive new leads for drug development will be highlighted.

Keywords: Terpenoids, lanostane, triterpene glycosides, ursane, lupane triterpenes, cucurbitacin, taraxerane

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Current Topics in Medicinal Chemistry

Title: Plant-derived Terpenoids and Analogues as Anti-HIV Agents

Volume: 3 Issue: 2

Author(s): Kuo-Hsiung Lee

Affiliation:

Keywords: Terpenoids, lanostane, triterpene glycosides, ursane, lupane triterpenes, cucurbitacin, taraxerane

Abstract: The plant-derived terpenoids and analogues are reviewed with respect to their anti-HIV activity, structure-activity relationships, and mechanism of action. The active compounds include diterpenoid lactones, phenolic diterpenes, atisane and kaurane diterpenes, phorbol diterpenes, triterpene glycosides, friedelane triterpenes, taraxerane triterpenes, ursane triterpenes, lanostane triterpene, lupane triterpenes, seco-ring A triterpenes, degraded triterpenes, and cucurbitacin triterpenes. Positive new leads for drug development will be highlighted.

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Lee Kuo-Hsiung, Plant-derived Terpenoids and Analogues as Anti-HIV Agents, Current Topics in Medicinal Chemistry 2003; 3 (2) . https://dx.doi.org/10.2174/1568026033392435