Inhibitors of Lysine Biosynthesis as Antibacterial Agents

Craig   A.   Hutton; Timothy   J.   Southwood; Jennifer   J.   Turner

doi:10.2174/1389557033405359

Abstract

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.

Keywords: lysine, dap pathway, diaminopimelate, antibiotics, enzyme inhibitors

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Mini-Reviews in Medicinal Chemistry

Title: Inhibitors of Lysine Biosynthesis as Antibacterial Agents

Volume: 3 Issue: 2

Author(s): Craig A. Hutton, Timothy J. Southwood and Jennifer J. Turner

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Keywords: lysine, dap pathway, diaminopimelate, antibiotics, enzyme inhibitors

Abstract: Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.

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Hutton A. Craig, Southwood J. Timothy and Turner J. Jennifer, Inhibitors of Lysine Biosynthesis as Antibacterial Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (2) . https://dx.doi.org/10.2174/1389557033405359